DETECTION OF THE GBV-C HEPATITIS-VIRUS GENOME IN SERUM FROM PATIENTS WITH FULMINANT-HEPATITIS OF UNKNOWN ETIOLOGY

被引：469

作者：

YOSHIBA, M

OKAMOTO, H

MISHIRO, S

机构：

[1] TOSHIBA GEN HOSP, DEPT MED SCI, SHINAGAWA KU, TOKYO 140, JAPAN

[2] SHOWA UNIV, FUJIGAOKA HOSP, SCH MED, DEPT GASTROENTEROL, YOKOHAMA, KANAGAWA 227, JAPAN

[3] JICHI MED SCH, DIV IMMUNOL, MINAMI KAWACHI, TOCHIGI 32904, JAPAN

来源：

LANCET | 1995年 / 346卷 / 8983期

关键词：

D O I：

10.1016/S0140-6736(95)91802-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hepatitis viruses A, B, C, D, and E have not accounted for all cases of hepatitis, hence ''non A-E'' agent(s) might be implicated. A set of new viruses (GBV-A, -B, and -C) whose genomes have been sequenced, are being investigated as possible causes of non A-E hepatitis. We investigated six cases of fulminant hepatitis of unknown aetiology for the presence of GBV-C genome in their serum, and three showed positive signals by semi-nested PCR using primers derived from the NS3/helicase region. Nucleotide sequence analyses confirmed these signals to be derived from a GBV-C sequence. The results suggest the importance of GBV-C in the aetiology of fulminant hepatitis.

引用

页码：1131 / 1132

页数：2

共 7 条

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