UNDERLYING DISORDERS ASSOCIATED WITH SEVERE EARLY-ONSET PREECLAMPSIA

被引:443
作者
DEKKER, GA
DEVRIES, JIP
DOELITZSCH, PM
HUIJGENS, PC
VONBLOMBERG, BME
JAKOBS, C
VANGEIJN, HP
机构
[1] FREE UNIV AMSTERDAM HOSP,DEPT PATHOL,1081 HV AMSTERDAM,NETHERLANDS
[2] FREE UNIV AMSTERDAM HOSP,DEPT PEDIAT,1081 HV AMSTERDAM,NETHERLANDS
[3] FREE UNIV AMSTERDAM HOSP,DEPT HAEMATOL,1081 HV AMSTERDAM,NETHERLANDS
关键词
PREECLAMPSIA; PROTEIN S DEFICIENCY; ACTIVATED PROTEIN C RESISTANCE; HYPERHOMOCYSTEINEMIA; ANTICARDIOLIPIN ANTIBODIES; CHRONIC HYPERTENSION;
D O I
10.1016/0002-9378(95)91324-6
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
OBJECTIVE: Our purpose was to determine whether patients with severe early-onset preeclampsia have hemostatic or metabolic abnormalities that are associated with a tendency to Vascular thrombosis. STUDY DESIGN: A total of 101 patients with a history of severe early-onset preeclampsia were tested at least 10 weeks post partum for the presence of hyperhomocysteinemia (methionine loading test), protein C, protein S, and antithrombin III deficiency activated protein C resistance, lupus anticoagulant, and immunoglobulin G and/or M anticardiolipin antibodies. RESULTS: Of the 101 patients, 39 (38.6%) had chronic hypertension. Of the 85 patients tested for coagulation disturbances, 21 (24.7%) had protein S deficiency. Of the 50 patients tested for activated protein C resistance, 8 (16.0%) were positive. Of the 79 patients tested for hyperhomocysteinemia, 14 (17.7%) had a positive methionine loading test. Finally, 95 patients were tested for anticardiolipin antibodies; 27 (29.4%) had detectable immunoglobulin G and/or M anticardiolipin antibodies. CONCLUSION: Patients with a history of severe early-onset preeclampsia should be screened for protein S deficiency, activated protein C resistance, hyperhomocysteinemia, and anticardiolipin antibodies, since these results may have an impact on counseling for and pharmacologic management in future pregnancies.
引用
收藏
页码:1042 / 1048
页数:7
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