A RAT GENE ENCODING HEART 6-PHOSPHOFRUCTO-2-KINASE FRUCTOSE-2,6-BISPHOSPHATASE

被引：33

作者：

DARVILLE, MI

CHIKRI, M

LEBEAU, E

HUE, L

ROUSSEAU, GG

机构：

[1] CATHOLIC UNIV LOUVAIN,SCH MED,B-1200 BRUSSELS,BELGIUM

[2] INT INST CELLULAR & MOLEC PATHOL,HORMONE & METAB RES UNIT,B-1200 BRUSSELS,BELGIUM

来源：

FEBS LETTERS | 1991年 / 288卷 / 1-2期

关键词：

FRUCTOSE-2,6-BISPHOSPHATASE; FRUCTOSE-2,6-BISPHOSPHATE; GLYCOLYSIS; 6-PHOSPHOFRUCTO-2-KINASE; GENE FUSION; RAT HEART;

D O I：

10.1016/0014-5793(91)81009-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There are at least 3 isozymes of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, a bifunctional enzyme which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate. A 22-kb rat gene that encodes the heart isozyme has been identified and compared with the 55-kb rat gene encoding the liver and muscle isozymes which had been described earlier. Although these 2 genes include 12 successive similar exons, they contain dissimilar exons at both ends, consistent with the occurrence of different regulatory domains at the N- and C-termini in the 3 isozymes.

引用

页码：91 / 94

页数：4

共 20 条

[1] EVOLUTION OF A BIFUNCTIONAL ENZYME - 6-PHOSPHOFRUCTO-2-KINASE FRUCTOSE-2,6-BISPHOSPHATASE [J].