INTERACTION OF THE ARYL TETRASACCHARIDE DOMAIN OF CALICHEAMICIN-GAMMA-1(I) WITH DNA - INFLUENCE ON AGLYCON AND METHIDIUMPROPYL-EDTA.IRON(II)-MEDIATED DNA CLEAVAGE

被引：73

作者：

AIYAR, J ^{[1
]}

DANISHEFSKY, SJ ^{[1
]}

CROTHERS, DM ^{[1
]}

机构：

[1] YALE UNIV,DEPT CHEM,NEW HAVEN,CT 06511

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1992年 / 114卷 / 19期

关键词：

D O I：

10.1021/ja00045a032

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This study assesses individual interactions of the oligosaccharide and aglycon domains of calicheamicin gamma-1I, an antitumor antibiotic, with DNA. Preincubation of DNA with the full carbohydrate domain followed by incubation with aglycon leads to sequence-selective cleavage not observed in the absence of the carbohydrate.

引用

页码：7552 / 7554

页数：3

共 33 条

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