POTENT INHIBITORS OF HISTAMINE-RELEASE, 2 NOVEL TRITERPENOIDS FROM THE OKINAWAN MARINE SPONGE PENARES-INCRUSTANS

被引：25

作者：

SHOJI, N

UMEYAMA, A

MOTOKI, S

ARIHARA, S

ISHIDA, T

NOMOTO, K

KOBAYASHI, J

TAKEI, M

机构：

[1] TOKUSHIMA BUNRI UNIV,FAC PHARMACEUT SCI,TOKUSHIMA 770,JAPAN

[2] OSAKA UNIV PHARMACEUT SCI,MATSUBARA,OSAKA 580,JAPAN

[3] SUNTORY INST BIOORGAN RES,SHIMAMOTO,OSAKA 618,JAPAN

[4] HOKKAIDO UNIV,FAC PHARMACEUT SCI,KITA KU,SAPPORO,HOKKAIDO 060,JAPAN

[5] LA JOLLA INST ALLERGY & IMMUNOL,LA JOLLA,CA 92937

来源：

JOURNAL OF NATURAL PRODUCTS | 1992年 / 55卷 / 11期

关键词：

D O I：

10.1021/np50089a021

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two novel triterpenoids with an unusual 14-carboxyl group, penasterone [1] and acetylpenasterol [2], were isolated from the Okinawan marine sponge Penares incrustans. The structures of 1 and 2 were established mainly on the basis of nmr spectroscopic data. The relative stereochemistry of 1 was confirmed by single-crystal X-ray diffraction analysis. Compounds 1 and 2 potently inhibited histamine release from rat peritoneal mast cells induced by anti-IgE in a dose-dependent manner.

引用

页码：1682 / 1685

页数：4

共 6 条

[1] PENASTEROL, A NOVEL ANTILEUKEMIC STEROL FROM THE OKINAWAN MARINE SPONGE PENARES SP [J].