EFFECT OF ANTACIDS IN DIDANOSINE TABLET ON BIOAVAILABILITY OF ISONIAZID

被引：16

作者：

GALLICANO, K

SAHAI, J

ZARORBEHRENS, G

PAKUTS, A

机构：

[1] OTTAWA GEN HOSP,DIV INFECT DIS,SOI SMYTH RD,OTTAWA K1H 8L6,ONTARIO,CANADA

[2] HLTH PROTECT BRANCH,SIR FREDERICK BANTING RES CTR,BUR DRUG RES,OTTAWA KI1 QL2,ON,CANADA

[3] HLTH PROTECT BRANCH,BUR HUMAN PRESCRIPT DRUGS HLTH,VANIER K1A 1B8,ON,CANADA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1994年 / 38卷 / 04期

关键词：

D O I：

10.1128/AAC.38.4.894

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The antacids in two didanosine placebo tablets had no significant effect on the plasma pharmacokinetics of a single oral dose of 300 mg of isoniazid administered to 12 healthy volunteers. These results suggest that isoniazid bioavailability will be unaffected hy the antacids in didanosine tablets when the two medications are administered simultaneously to human immunodeficiency virus-seropositive patients.

引用

页码：894 / 897

页数：4

共 16 条

[1]

BERNING SE, 1992, NEW ENGL J MED, V327, P1817, DOI 10.1056/NEJM199212173272514

[2]

EISUD L, 1974, REV CAN BIOL, V33, P117

[3] QUALITATIVE AND QUANTITATIVE DRUG-SUSCEPTIBILITY TESTS IN MYCOBACTERIOLOGY [J].