S-ADENOSYL-L-METHIONINE AMELIORATES REDUCED LOCAL CEREBRAL GLUCOSE-UTILIZATION FOLLOWING BRAIN ISCHEMIA IN THE RAT

被引:7
作者
KOBAYASHI, K
NAKAJIMA, E
KUBO, Y
YASUKAWA, Y
IWATA, N
机构
[1] SANKYO CO LTD,BIOL RES LABS,HIROMACHI 1-2-58,SHINAGAWA KU,TOKYO 140,JAPAN
[2] SANKYO CO LTD,ANALYT & METAB RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
关键词
D O I
10.1254/jjp.52.141
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The average values of the local cerebral glucose utilization (LCGU) were approx. 35-110 µzmol/100 g/min in various nuclei in the brain of sham-operated animals. The values, however, were decreased by 25-75% in all areas examined at 24 hr after 4-vessel occlusion (forebrain ischemia) for 0.5 hr. Particularly, the LCGU values in the forebrain nuclei such as the cerebral cortices and thalamus were severely reduced, while that in the nuclei in the midbrain and hindbrain such as the red nucleus, chochlear nucleus and vestibular nucleus were slightly reduced. In rats treated with S-adenosyl-L-methionine (SAM, 1 00 mg/kg, i.p.) every 1 hr for 6 times from the recirculation, however, the LCGU values were increased in all brain structures by 35-195% in the forebrain ischemic rat. A significant increase was observed in the cerebral neocortices, caudate-putamen, lateral septal nucleus, thalamic nuclei, substantia nigra, cerebellum and some other nuclei. In some forebrain structures whose LCGU were mildly reduced to approx. 60-70% by the ischemia, SAM recovered the LCGU to more than 90% of the value in the sham-operated group. Thus it was concluded that SAM ameliorated widely ischemia-induced reduction of LCGU in the rat. © 1990, The Japanese Pharmacological Society. All rights reserved.
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页码:141 / 148
页数:8
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