MICROSPHERES OF HYALURONIC-ACID ESTERS - FABRICATION METHODS AND INVITRO HYDROCORTISONE RELEASE

被引:61
作者
BENEDETTI, LM [1 ]
TOPP, EM [1 ]
STELLA, VJ [1 ]
机构
[1] UNIV KANSAS,DEPT PHARMACEUT CHEM,LAWRENCE,KS 66045
关键词
hyaluronic acid esters; hydrocortisone; in vitro drug release; microspheres; polymeric prodrugs;
D O I
10.1016/0168-3659(90)90072-2
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Microspheres 10 to 100 μm in diameter have been prepared from various esters of hyaluronic acid using a solvent evaporation method. A model compound, hydrocortisone, has been incorporated into these microspheres. The drug can be either physically dispersed in the polymer matrix, or chemically bound to the polymer backbone through an ester linkage. When the drug was physically dispersed, its release into a well-stirred buffer solution was essentially complete in 10 minutes. When the drug was covalently bound to the polymer, the release was much slower, requiring more than 100 hours in some cases. The release rate of covalently bound drug was found to be constant (zero order) over most of the release period. The release of covalently bound drug is thought to be controlled primarily by the hydrolysis of the ester bond. © 1990.
引用
收藏
页码:33 / 41
页数:9
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