THERAPEUTIC EFFECTS OF HYPERBARIC OXYGENATION ON ACUTE FOCAL CEREBRAL-ISCHEMIA IN RATS

被引：44

作者：

KAWAMURA, S ^{[1
]}

YASUI, N ^{[1
]}

SHIRASAWA, M ^{[1
]}

FUKASAWA, H ^{[1
]}

机构：

[1] RES INST BRAIN & BLOOD VESSELS,DEPT PATHOL,AKITA,JAPAN

来源：

SURGICAL NEUROLOGY | 1990年 / 34卷 / 02期

关键词：

Cerebral edema; Cerebral ischemia; Hyperbaric oxygen; Middle cerebral artery occlusion; Rat;

D O I：

10.1016/0090-3019(90)90104-W

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The effects of hyperbaric oxygenation on acute focal cerebral ischemia in rats were investigated. All rats suffered 4-hour middle cerebral artery occlusion. Nontreated controls had a 27.9% ± 5.5% infarct volume, and a left/right hemispheric volume ratio of 109% ± 3%. Animals treated between 2.5 and 3.5 hours following occlusion had an 18.1% ± 9.7% infarct volume (p < 0.01), and a 105% ± 3% left/right hemispheric volume ratio (p < 0.001). In conclusion, at least until 4 hours following an ischemic insult, hyperbaric oxygenation reduces ischemic neuronal injury and brain edema following middle cerebral artery occlusion in rats treated between 2.5 and 3.5 hours following occlusion. © 1990.

引用

页码：101 / 106

页数：6

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