COMPLETE WATER SUPPRESSION FOR SOLUTIONS OF LARGE MOLECULES BASED ON DIFFUSIONAL DIFFERENCES BETWEEN SOLUTE AND SOLVENT (DRYCLEAN)

A method is outlined for suppressing water in proton spectra using differences in its diffusion properties with the solutes. Solute protons at the water resonance frequency can be studied, the spectrum is not phase-distorted, and success of the technique does not depend on B1 homogeneity or water linewidth. No phase cycling is necessary and suppression is easier for larger solutes. © 1990.