MODELS OF HEPATIC DRUG CLEARANCE - DISCRIMINATION BETWEEN THE WELL STIRRED AND PARALLEL-TUBE MODELS

被引:86
作者
AHMAD, AB
BENNETT, PN
ROWLAND, M
机构
[1] UNIV BATH,SCH PHARM & PHARMACOL,BATH BA2 7AY,AVON,ENGLAND
[2] UNIV MANCHESTER,DEPT PHARM,MANCHESTER M13 9PL,LANCS,ENGLAND
关键词
D O I
10.1111/j.2042-7158.1983.tb02916.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:219 / 224
页数:6
相关论文
共 15 条
[1]   LIVER PERFUSION TECHNIQUE USING INEXPENSIVE NON-BINDING MEDIUM FOR 1ST-PASS METABOLISM STUDIES OF DRUGS [J].
BEAUBIEN, AR ;
TRYPHONAS, L ;
PAKUTS, AP ;
MACCONAILL, M ;
COMBLEY, HA .
JOURNAL OF PHARMACOLOGICAL METHODS, 1979, 2 (03) :213-221
[2]  
BENOWITZ N, 1974, CLIN PHARM THER, V16, P84
[3]  
BISHOFF KB, 1971, J PHARM SCI, V60, P1128
[4]   INCREASED CLEARANCE OF ANTIPYRINE AND D-PROPRANOLOL AFTER PHENOBARBITAL TREATMENT IN MONKEY - RELATIVE CONTRIBUTIONS OF ENZYME-INDUCTION AND INCREASED HEPATIC BLOOD-FLOW [J].
BRANCH, RA ;
SHAND, DG ;
WILKINSON, GR ;
NIES, AS .
JOURNAL OF CLINICAL INVESTIGATION, 1974, 53 (04) :1101-1107
[5]  
KEIDING S, 1978, J PHARMACOL EXP THER, V205, P465
[6]  
LENNARD MS, 1978, CLIN SCI MOL MED, V55, pP5
[7]   MEPERIDINE AND OTHER BASIC DRUGS - GENERAL METHOD FOR THEIR DETERMINATION IN PLASMA [J].
MATHER, LE ;
TUCKER, GT .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1974, 63 (02) :306-307
[8]  
Pang K S, 1977, J Pharmacokinet Biopharm, V5, P625, DOI 10.1007/BF01059688
[9]  
Pang K S, 1977, J Pharmacokinet Biopharm, V5, P655, DOI 10.1007/BF01059689
[10]   CLEARANCE CONCEPTS IN PHARMACOKINETICS [J].
ROWLAND, M ;
BENET, LZ ;
GRAHAM, GG .
JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1973, 1 (02) :123-136