A VERSATILE SOLID-PHASE METHOD FOR THE SYNTHESIS OF OLIGONUCLEOTIDE-3'-PHOSPHATES

被引：33

作者：

KUMAR, P ^{[1
]}

BOSE, NK ^{[1
]}

GUPTA, KC ^{[1
]}

机构：

[1] VP CHEST INST BLDG,CSIR,CTR BIOCHEM,NUCLEIC ACIDS RES LAB,DELHI 110007,INDIA

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 07期

关键词：

D O I：

10.1016/S0040-4039(00)92132-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The polymer support 6 with 4,4'-dimethoxytrityloxy-2-mercaptoethyl group allows the automated oligonucleotide synthesis giving rise to oligonucleotide-3'-phosphate during final deprotection with ammonical DTT at 55-degrees-C.

引用

页码：967 / 970

页数：4

共 11 条

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[6] PHOSPHOCYTIDINES AS VERSATILE 3' PROTECTING GROUPS IN TRIESTER SYNTHESIS OF OLIGODEOXYRIBONUCLEOTIDES
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[J]. TETRAHEDRON LETTERS, 1983, 24 (48) : 5317 - 5320
[7] MARKIEWICZ WT, 1989, NUCLEIC ACIDS RES, V7, P7149
[8] PURMAL AA, 1984, BIOORG KHIM+, V10, P394
[9] DNA-LIKE DUPLEXES WITH REPETITIONS .3. EFFICIENT TEMPLATE-GUIDED CHEMICAL POLYMERIZATION OF D(TGGCCAAGCTP)
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[J]. NUCLEIC ACIDS RESEARCH, 1981, 9 (21) : 5747 - 5761
[10] THUONG NT, 1981, B SOC CHIM FR II-CH, P51

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