PERTUSSIS TOXIN-SENSITIVE G-PROTEIN ACTIVATION DOES NOT INFLUENCE THE RESPONSE TO BAY-K 8644 IN EMBRYONIC CHICK MYOCYTES

被引：4

作者：

ANDERSON, AJ ^{[1
]}

DUNCAN, GP ^{[1
]}

SPEDDING, M ^{[1
]}

PATMORE, L ^{[1
]}

机构：

[1] HERIOT WATT UNIV,SYNTEX RES CTR,RES PK,EDINBURGH EH14 4AP,SCOTLAND

来源：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 1990年 / 16卷 / 04期

关键词：

Calcium channel agonists; Calcium channel currents; Embryonic chick myocytes; G proteins;

D O I：

10.1097/00005344-199010000-00023

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pretreatment of embryonic chick cardiac myocytes with pertussis toxin (1-2.5 μg ml-1 for 22 h) abolished the negative chronotropic effects of carbachol but not the positive inotropic effects of Bay K 8644. Neither guanosine 5'-O-3-thiotriphosphate (GTPγS 500 μM intra-cellularly), nor pertussis toxin (0.5-1 μg ml-1 for 22 h) modified the agonist effects of Bay K 8644 on calcium channel currents recorded under whole-cell voltage clamp. These findings indicate that pertussis-sensitive guanine nucleotide binding (G)-proteins does not modulate the effects of calcium channel activators in embryonic chick cardiac myocytes. © 1990 Raven Press, Ltd., New York.

引用

页码：681 / 683

页数：3

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