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USE OF SILICA WITH REVERSED-PHASE TYPE ELUENTS FOR THE ANALYSIS OF BASIC DRUGS AND METABOLITES

被引：29
作者：
LAW, B
机构：
[1] Safety of Medicines Department, ICI Pharmaceuticals, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom
来源：
TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 1990年 / 9卷 / 01期
关键词：
Chromatographic Analysis--High Performance Liquid - Metabolite--Chromatographic Analysis - Organic Compounds--Chemical Analysis - Silica--Applications;
D O I：
10.1016/0165-9936(90)80014-Y
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The use of silica with simple methanol-buffer elements offers a powerful and versatile approach to the analysis of a wide range of basic drugs and their metabolites. Chromatographic performance is good and the retention characteristics, particularly of drug metabolites, can be easily predicted. The system is particularly suited to bioanalysis, offering good selectivity with respect to endogenous compounds.
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页码：31 / 36
页数：6
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