HEPATOCYTE GROWTH-FACTOR HEPATOPOIETIN-A STIMULATES THE GROWTH OF RAT-KIDNEY PROXIMAL TUBULE EPITHELIAL-CELLS (RPTE), RAT NONPARENCHYMAL LIVER-CELLS, HUMAN-MELANOMA CELLS, MOUSE KERATINOCYTES AND STIMULATES ANCHORAGE-INDEPENDENT GROWTH OF SV40-TRANSFORMED RPTE

被引：273

作者：

KAN, M ^{[1
]}

ZHANG, GH ^{[1
]}

ZARNEGAR, R ^{[1
]}

MICHALOPOULOS, G ^{[1
]}

MYOKEN, Y ^{[1
]}

MCKEEHAN, WL ^{[1
]}

STEVENS, JL ^{[1
]}

机构：

[1] DUKE UNIV,COMPREHENS MED CTR,DEPT PATHOL,DURHAM,NC 27710

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 174卷 / 01期

关键词：

D O I：

10.1016/0006-291X(91)90524-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hepatocyte growth factor/hepatopoietin A is a mitogen for primary hepatocytes and may mediate regeneration after liver damage. To date, the activity of this novel factor has been restricted to hepatocytes. We now show that the factor is also a mitogen for a number of primary epithelial cells but is inactive with human foreskin fibroblasts, human endothelial cells and HEP3B cells. The factor also substitutes for HBGF-2 (basic FGF) in stimulating the anchorage-independent growth of SV-40 transformed rat kidney epithelial cells. Therefore, hepatocyte growth factor/hepatopoietin A appears to act on a variety of epithelial, but not mesenchymal, cells which respond to HBGFs. © 1991.

引用

页码：331 / 337

页数：7

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