INVITRO RELEASE OF HYDROCORTISONE FROM TOPICAL PREPARATIONS AND AUTOMATED PROCEDURE

被引：61

作者：

SHAH, VP ^{[1
]}

ELKINS, J ^{[1
]}

HANUS, J ^{[1
]}

NOORIZADEH, C ^{[1
]}

SKELLY, JP ^{[1
]}

机构：

[1] DALLAS DIST LAB,DALLAS,TX

来源：

PHARMACEUTICAL RESEARCH | 1991年 / 8卷 / 01期

关键词：

INVITRO RELEASE FOR CREAMS; OINTMENTS; LOTIONS; DIFFUSION CELL; SYNTHETIC MEMBRANES; AUTOMATION; HYDROCORTISONE;

D O I：

10.1023/A:1015826205930

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The in vitro drug release profile of hydrocortisone (HC) from creams, ointments, and lotions has been determined using an automated procedure. A diffusion cell system and commercially available synthetic membranes were utilized for the studies. The use of a synthetic membrane obviates the problems associated with using skin membranes. Uniform creams and ointment samples for determining release rate profile were prepared by using the teflon mask. Automated sampling avoids operator artifacts. The automated technique developed for determining the in vitro release rate profile of the drug from creams, ointments, and lotions using a diffusion-cell system appears to be a reasonable and practical procedure for assuring batch-to-batch uniformity of topical drug products.

引用

页码：55 / 59

页数：5

共 13 条

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