TRYPANOSOMA-CRUZI - CALCIUM-ION MOVEMENT DURING INTERNALIZATION IN HOST HELA-CELLS

被引：27

作者：

OSUNA, A

CASTANYS, S

RODRIGUEZCABEZAS, MN

GAMARRO, F

机构：

[1] Laboratory of Molecular Parasitology, Institute of Biotechnology, University of Granada, Granada, E-18071, Science Faculty Campus Fuente Nueva C/Severo Ochoa

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 1990年 / 20卷 / 05期

关键词：

calcium ion movement; calmodulin inhibitors; EDTA; Haloperidol; HeLa cells; IBMX; parasite-cell interaction; Phenothiazine; Pimozide; Procaine; protozoa; theophylline; Trifluoroperazine; Trypanosoma cruzi; Verapamil;

D O I：

10.1016/0020-7519(90)90126-8

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The role of cytosolic Ca2+ and cytoplasmic calcium movement during the parasitization of HeLa cells by T. cruzi were studied. The level of calcium in parasitized cells increased compared to the control cells. Our experiments demonstrate that this cytosolic calcium originates from the release of the intracellular calcium deposits, especially from the mitochondria of the host cell. The parasitization rates decreased after the cells were treated with drugs to increase the cytosolic Ca2+ levels to inhibit the host-cell calmodulin. © 1990.

引用

页码：673 / 676

页数：4

共 21 条

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