CORRELATION OF THE SURFACE HYDROPHOBICITY OF C-14 POLY (METHYL-METHACRYLATE) NANOPARTICLES TO THEIR BODY DISTRIBUTION

被引：34

作者：

TROSTER, SD

WALLIS, KH

MULLER, RH

KREUTER, J

机构：

[1] UNIV KIEL,DEPT PHARMACEUT & BIOPHARMACEUT,GUTENBERGSTR 76-78,W-2300 KIEL 1,GERMANY

[2] UNIV FRANKFURT,INST PHARMACEUT TECHNOL,W-6000 FRANKFURT 1,GERMANY

[3] FREE UNIV BERLIN,DEPT PHARMACEUT & BIOPHARMACEUT,W-1000 BERLIN 33,GERMANY

来源：

JOURNAL OF CONTROLLED RELEASE | 1992年 / 20卷 / 03期

关键词：

POLY (METHYL-METHACRYLATE) NANOPARTICLES; POLOXAMINE; ETHOXYLATED NONYLPHENOLS; SURFACE MODIFICATION; ORGAN DISTRIBUTION; SURFACE HYDROPHOBICITY; ZETA-POTENTIAL;

D O I：

10.1016/0168-3659(92)90127-D

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Poly(methyl methacrylate) nanoparticles for intravenous injection were surface-modified by the adsorption of poloxamine 908, Antarox DM 970 and Klucel EF. The coated particles were characterized in parameters relevant to their in vivo distribution: adsorption layer thickness, particle charge, surface hydrophobicity, interaction with serum components. The body distribution of the C-14-labeled particles was determined after i.v. injection into rats over 7 days and correlated to the in vitro characterization data. The physicochemical characterization methods allowed to identify carriers which will be taken up by liver and spleen macrophages in vivo. Coating materials with potential protective effect against uptake could be placed in order of increasing efficiency.

引用

页码：247 / 260

页数：14

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