SYMMETRICAL CHROMOSOME REARRANGEMENTS IN CELL-LINES ESTABLISHED FROM HUMAN RADIATION-INDUCED SARCOMAS

被引：21

作者：

COWAN, JM ^{[1
]}

BECKETT, MA ^{[1
]}

TARBELL, N ^{[1
]}

WEICHSELBAUM, RR ^{[1
]}

机构：

[1] CHILDRENS HOSP MED CTR,BOSTON,MA 02115

来源：

CANCER GENETICS AND CYTOGENETICS | 1990年 / 50卷 / 01期

关键词：

D O I：

10.1016/0165-4608(90)90246-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report the establishment of cell lines from six radiation-induced tumors, three osteosarcomas, and three soft tissue sarcomas. Cytogenetic analysis of the lines showed mostly balanced rearrangements in the osteosarcomas; the soft tissue sarcomas had more unstable karyotypes. The rearrangements observed were unlike those previously reported for spontaneously occurring tumors of the same histological type and were more typical of the long-term changes observed after radiation exposure. © 1990.

引用

页码：125 / 137

页数：13

共 35 条

[1]

ABRAMSON DH, 1984, OPHTHALMOLOGY, V91, P1351

[2] COMPLEX KARYOTYPES IN A SERIES OF PEDIATRIC OSTEOSARCOMAS [J].