BIOACTIVE ERGOST-5-ENE-3-BETA,7-ALPHA-DIOL DERIVATIVES FROM PSEUDOBERSAMA-MOSSAMBICENSIS

被引：65

作者：

GUNATILAKA, AAL

SAMARANAYAKE, G

KINGSTON, DGI

HOFFMANN, G

JOHNSON, RK

机构：

[1] VIRGINIA POLYTECH INST & STATE UNIV,DEPT CHEM,BLACKSBURG,VA 24061

[2] SMITHKLINE BEECHAM PHARMACEUT,RES & DEV,KING OF PRUSSIA,PA 19406

来源：

JOURNAL OF NATURAL PRODUCTS | 1992年 / 55卷 / 11期

关键词：

D O I：

10.1021/np50089a014

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioactivity-directed fractionation of the methyl ethyl ketone extract of Pseudobersama mossambicensis resulted in the isolation of ergosta-5,24(28)-diene-3beta,7alpha-diol[1], 24,28-epoxyergost-5-ene-3beta,7alpha-diol [2], and ergost-5-ene-3beta,7alpha,24,28-tetraol [3]. All three sterols showed selective activity towards DNA repair-deficient yeast mutants. The sterol 1 also showed cytotoxicity towards wild-type P-388 murine leukemia cells. The isolation, structural elucidation, and biological activities of these sterols are reported. The sterol 3 is most probably an artifact formed from 2 during the isolation process.

引用

页码：1648 / 1654

页数：7

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