INTERACTION BETWEEN FLUVOXAMINE AND IMIPRAMINE DESIPRAMINE IN 4 PATIENTS

被引：69

作者：

SPINA, E ^{[1
]}

CAMPO, GM ^{[1
]}

AVENOSO, A ^{[1
]}

POLLICINO, MA ^{[1
]}

CAPUTI, AP ^{[1
]}

机构：

[1] CTR MENTAL HLTH,MESSINA,ITALY

来源：

THERAPEUTIC DRUG MONITORING | 1992年 / 14卷 / 03期

关键词：

TRICYCLIC ANTIDEPRESSANTS; IMIPRAMINE; DESIPRAMINE; FLUVOXAMINE; DRUG INTERACTION;

D O I：

10.1097/00007691-199206000-00004

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

We describe four patients in whom the addition of fluvoxamine (100 mg/day) to the treatment with imipramine or desipramine (100-150 mg/day) resulted in a dramatic increase in the plasma concentrations of the tricyclic antidepressants associated with adverse effects. These observations indicate that fluvoxamine inhibits both the demethylation of imipramine and, possibly to a lesser extent, the hydroxylation of desipramine. The combination of fluvoxamine with tricyclic antidepressants should be avoided whenever possible.

引用

页码：194 / 196

页数：3

共 11 条

[1]

ARANOW RB, 1989, AM J PSYCHIAT, V146, P911

[2] FLUVOXAMINE - A REVIEW OF ITS PHARMACODYNAMIC AND PHARMACOKINETIC PROPERTIES, AND THERAPEUTIC EFFICACY IN DEPRESSIVE-ILLNESS [J].