ACTION OF EXTERNALLY APPLIED ATP ON RAT RETICULOSPINAL VASOMOTOR NEURONS

被引:60
作者
SUN, MK
WAHLESTEDT, C
REIS, DJ
机构
[1] Division of Neurobiology, Department of Neurology and Neuroscience, Cornell University Medical College, New York, NY 10021
关键词
ATP; ROSTRAL VENTROLATERAL MEDULLA; VASOMOTOR NEURONS;
D O I
10.1016/0014-2999(92)94824-F
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
In anesthetized rats, iontophoretic application of ATP excited the spinal cord-projection neurons in the rostral ventrolateral reticular nucleus of the medulla oblongata. The neuronal response to ATP was mimicked and then blocked by alpha,beta-methylene-ATP, a metabolically stable ATP analogue, and the response was abolished by suramin. Microinjections of ATP (3-100 pmol) into the rostral ventrolateral medulla produced a powerful pressor response. The results suggest that ATP may function as a neurotransmitter or neuromodulator involved in medullary regulation of cardiovascular functions.
引用
收藏
页码:93 / 96
页数:4
相关论文
共 10 条
[1]   SURAMIN - A REVERSIBLE P2-PURINOCEPTOR ANTAGONIST IN THE MOUSE VASDEFERENS [J].
DUNN, PM ;
BLAKELEY, AGH .
BRITISH JOURNAL OF PHARMACOLOGY, 1988, 93 (02) :243-245
[2]   ATP MEDIATES FAST SYNAPTIC TRANSMISSION IN MAMMALIAN NEURONS [J].
EVANS, RJ ;
DERKACH, V ;
SURPRENANT, A .
NATURE, 1992, 357 (6378) :503-505
[3]   THE LIBERATION OF ADENOSINE TRIPHOSPHATE ON ANTIDROMIC STIMULATION OF SENSORY NERVES [J].
HOLTON, P .
JOURNAL OF PHYSIOLOGY-LONDON, 1959, 145 (03) :494-504
[4]   ATP EXCITES A SUBPOPULATION OF RAT DORSAL HORN NEURONS [J].
JAHR, CE ;
JESSELL, TM .
NATURE, 1983, 304 (5928) :730-733
[5]  
KUGELGEN IV, 1991, TRENDS PHARMACOL SCI, V12, P319
[6]   FURTHER SUBCLASSIFICATION OF ATP RECEPTORS BASED ON AGONIST STUDIES [J].
OCONNOR, SE ;
DAINTY, IA ;
LEFF, P .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1991, 12 (04) :137-141
[7]  
REIS DJ, 1988, HYPERTENSION, V11, P8
[8]   HYPOTHALAMIC GLUTAMATERGIC INPUT TO MEDULLARY SYMPATHOEXCITATORY NEURONS IN RATS [J].
SUN, MK ;
GUYENET, PG .
AMERICAN JOURNAL OF PHYSIOLOGY, 1986, 251 (04) :R798-R810
[9]   INOSITOL HEXAKISPHOSPHATE EXCITES RAT MEDULLARY SYMPATHOEXCITATORY NEURONS INVIVO [J].
SUN, MK ;
WAHLESTEDT, C ;
REIS, DJ .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1992, 215 (01) :9-16
[10]   MULTIPLE TYPES OF NEURONAL CALCIUM CHANNELS AND THEIR SELECTIVE MODULATION [J].
TSIEN, RW ;
LIPSCOMBE, D ;
MADISON, DV ;
BLEY, KR ;
FOX, AP .
TRENDS IN NEUROSCIENCES, 1988, 11 (10) :431-438