A NEW IMMUNOSTIMULATORY COMPLEX (PICKCA) IN EXPERIMENTAL RABIES - ANTIVIRAL AND ADJUVANT EFFECTS

被引：17

作者：

LIN, HX

GONTIER, C

SARON, MF

PERRIN, P

机构：

[1] INST PASTEUR,RABIES UNIT,25 RUE DR ROUX,F-75724 PARIS 15,FRANCE

[2] INST PASTEUR,EXPTL VIROL LAB,F-75724 PARIS 15,FRANCE

[3] NATL INST CONTROL PHARMACEUT & BIOL PROD,BEIJING,PEOPLES R CHINA

来源：

ARCHIVES OF VIROLOGY | 1993年 / 131卷 / 3-4期

关键词：

D O I：

10.1007/BF01378634

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The activity of an immunostimulatory complex (PICKCa) which is widely used against several human diseases in China was tested in experimental rabies prophylaxis. PICKCa protected mice against peripheral infection with both fixed and wild rabies strains. It also enhanced the protective activity of an experimental rabies vaccine injected either before or after rabies infection. PICKCa enhanced both non-specific immune responses and specific immunity including antibody production and cell mediated immunity as assessed by interleukin-2 production.

引用

页码：307 / 319

页数：13

共 32 条

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