TETANUS AND BOTULISM NEUROTOXINS - A NEW GROUP OF ZINC PROTEASES

被引：204

作者：

MONTECUCCO, C

SCHIAVO, G

机构：

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1993年 / 18卷 / 09期

关键词：

D O I：

10.1016/0968-0004(93)90065-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The active forms of tetanus and botulinum neurotoxins, released from the precursor molecule by specific proteolysis and reduction, block the release of neurotransmitters via a Zn2+-dependent protease activity. VAMP/synaptobrevin, an integral membrane protein of the synaptic vesicles, is cleaved at a single site by tetanus and botulinum B, D and F neurotoxins. The unique sequence, mechanism of activation and site of activity of clostridial neurotoxins mark them out as an independent group of Zn2+-endopeptidases.

引用

页码：324 / 327

页数：4

共 38 条

[1] SYNAPTOBREVIN - AN INTEGRAL MEMBRANE-PROTEIN OF 18000 DALTONS PRESENT IN SMALL SYNAPTIC VESICLES OF RAT-BRAIN [J].