CYTOTOXIC FLAVONOLIGNANS AND FLAVONES FROM VERBASCUM-SINAITICUM LEAVES

被引：63

作者：

AFIFI, MSA

AHMED, MM

PEZZUTO, JM

KINGHORN, AD

机构：

[1] UNIV ILLINOIS,COLL PHARM,DEPT MED CHEM & PHARMACOGNOSY,PROGRAM COLLABORAT RES PHARMACEUT SCI,CHICAGO,IL 60612

[2] MANSOURA UNIV,FAC PHARM,DEPT PHARMACOGNOSY,MANSOURA,EGYPT

来源：

PHYTOCHEMISTRY | 1993年 / 34卷 / 03期

关键词：

VERBASCUM-SINAITICUM; SCROPHULARIACEAE; LEAVES; FLAVONOLIGNANS; HYDNOCARPIN; SINAITICIN; FLAVONES; CHRYSOERIOL; LUTEOLIN; CYTOTOXICITY;

D O I：

10.1016/0031-9422(93)85369-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Investigation of the leaves of Verbascum sinaiticum has afforded two flavonolignans, hydrocarpin and the novel sinaiticin, as well as two flavones, chrysoeriol and luteolin. All compounds exhibited dose-dependent cytotoxicity when tested against cultured P-388 cells.

引用

页码：839 / 841

页数：3

共 13 条

[1]

ANTUS S, 1986, LIEBIGS ANN CHEM, P647

[2] POTENTIAL ANTICANCER AGENTS .31. N-DEMETHYLATION OF FAGARONINE [J].

ARISAWA, M ;

PEZZUTO, JM ;

BEVELLE, C ;

CORDELL, GA .

JOURNAL OF NATURAL PRODUCTS, 1984, 47 (03) :453-458

[3] STRUCTURE DETERMINATION AND SPECTRAL ASSIGNMENT BY PULSED POLARIZATION TRANSFER VIA LONG-RANGE H-1-C-13 COUPLINGS [J].

BAX, A .

JOURNAL OF MAGNETIC RESONANCE, 1984, 57 (02) :314-318

[4] FLAVONOIDS, FLAVONOLIGNANS AND A PHENYLPROPANOID FROM ONOPORDON-CORYMBOSUM [J].

CARDONA, ML ;

GARCIA, B ;

PEDRO, JR ;

SINISTERRA, JF .

PHYTOCHEMISTRY, 1990, 29 (02) :629-631

[5]

GUNTER H, 1980, NMR SPECTROSCOPY INT

[6]

Harborne J. B., 1982, FLAVONOIDS ADV RES

[7]

KOSTOVA I, 1977, INDIAN J CHEM B, V15, P764

[8]

Mabry T.J., 1970, SYSTEMATIC IDENTIFIC, DOI [10.1007/978-3-642-88458-0_4, DOI 10.1007/978-3-642-88458-0_4]

[9]

Markham K.R, 1982, TECHNIQUES FLAVONOID

[10]

MUSCHLER R, 1912, MANUAL FLORA EGYPT, V2, P861

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