IMPAIRED GASTRIC-MUCOSAL ENERGY-METABOLISM IN CONGESTIVE GASTROPATHY IN CIRRHOTIC-PATIENTS

被引：9

作者：

KAWANO, S

TANIMURA, H

TSUJI, S

TAKEI, Y

NAGANO, K

KASHIWAGI, T

FUSAMOTO, H

KAMADA, T

机构：

[1] First Department of Medicine, Osaka University School of Medicine, Suita, 565

来源：

JOURNAL OF GASTROENTEROLOGY | 1994年 / 29卷 / 03期

关键词：

CONGESTIVE GASTROPATHY; ENERGY METABOLISM; GASTRIC MUCOSAL HEMODYNAMICS; LIVER CIRRHOSIS; REFLECTANCE SPECTROPHOTOMETRY;

D O I：

10.1007/BF02358361

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

To clarify the characteristics of congestive gastropathy, we investigated gastric mucosal hemodynamics and energy metabolism in cirrhotic patients, using a reflectance spectrophotometry system and high performance liquid chromatography. The index of the gastric mucosal blood volume of cirrhotic patients with esophageal varices was significantly higher, and the index of gastric mucosal blood oxygenation significantly lower, than those in controls, thus indicating congestion and hypoxia in the gastric mucosa. Energy charge levels in the gastric mucosa of cirrhotic patients with esophageal varices were also significantly decreased. The energy charge level showed a strong linear correlation with the index of mucosal blood oxygenation in the antral (r = 0.996, P < 0.01) and body (r = 0.994, P < 0.01) mucosa of the stomach. These findings suggest that congestive gastropathy in a portal hypertensive state causes hypoxia in the gastric mucosa, leading to a mucosal energy deficit that may increase mucosal susceptibility to aggressive factors.

引用

页码：245 / 249

页数：5

共 26 条

[1]

Papazian A., Braillon A., Dupas J.L., Et al., Portal hypertensive gastric mucosa

[2]

an endoscopic study, Gut, 27, pp. 1199-1203, (1986)

[3]

Swisher P.W., Baker A.L., Bennet D.H., Peptic ulcer in Laennec's cirrhosis, Am J Dig Dis, 22, pp. 291-294, (1955)

[4]

McCormack T.T., Si I., Eyre-Brook I., Et al., Gastric lesions in portal hypertension: Inflammatory gastritis or congestive gastropathy?, Gut, 26, pp. 1226-1232, (1985)

[5]

Ostrow J.D., Timmerman R.J., Cray S.J., Gastric secretion in human hepatic cirrhosis, Gastroenterology, 38, pp. 303-313, (1960)

[6]

Scobie B.A., Summerskill W.H.J., Reduced gastric acid output in cirrhosis: Quantitation and relationship, Gut, 5, pp. 422-428, (1954)

[7]

Lam S.K., Hypergastrinemia in cirrhosis of liver, Gut, 17, pp. 700-708, (1976)

[8]

Quintero E., Pique J.M., Bombi J.A., Et al., Gastric mucosal vascular ectasis causing bleeding in cirrhosis, Gastroenterology, 93, pp. 1054-1061, (1987)

[9]

Pique J.M., Leung F.W., Kitahora T., Et al., Gastric mucosal blood flow and acid secretion in portal hypertensive rats, Gastroenterology, 95, pp. 723-727, (1988)

[10]

Vorobioff J., Bredfeldt J.E., Groszmann R.J., Hyperdynamic circulation in portal-hypertensive rat model: A primary factor for maintenance of chronic portal hypertension, Am J Physiol, 244, pp. G52-G57, (1983)

← 1 2 3 →