A POTENTIAL SOFT-TISSUE FILLING MATERIAL - CHLORAMPHENICOL LOADED POLY(D,L-LACTIDE) SPONGES

被引:6
作者
KOZLUCA, A
DENKBAS, EB
PISKIN, E
机构
[1] HACETTEPE UNIV,DIV BIOENGN,ANKARA 06420,TURKEY
[2] HACETTEPE UNIV,DEPT CHEM ENGN,ANKARA,TURKEY
关键词
SOFT TISSUE; FILLING MATERIAL; PDLLA SPONGE; CHLORAMPHENICOL LOADING AND RELEASE;
D O I
10.1111/j.1525-1594.1995.tb02449.x
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Poly(D,L-lactide) (PDLLA) homopolymers were produced by the ring opening polymerization of a D,L-lactide dimer by using stannous chloride as the catalyst. Chloramphenicol loaded PDLLA sponges were prepared by a solvent evaporation procedure by using the PDLLA homopolymers with three different molecular weights (i.e., 11,000, 20,000 and 35,000 daltons). Chloramphenicol loading was changed by using three different solvents (i.e., acetone, ethyl acetate, and acetonitrile) and by changing the initial polymer concentration and its molecular weight and the initial concentration of the drug. Higher degradation rates of the chloramphenicol loaded PDLLA sponges in alkaline pH 9.0 and at 37 degrees C were observed. Chloramphenicol release rates were also high at these conditions. It was concluded that chloramphenicol release was both degradation and diffusion controlled.
引用
收藏
页码:902 / 908
页数:7
相关论文
共 21 条
[1]  
Guldian J, Jelenko C, Callaway, Et al., A comparative study of synthetic and biological materials for wound dressings, J Trauma, 13, (1973)
[2]  
Park GB., Burn and wound covering: A critical review, Biomat Med Dev Artif Organs, 6, (1978)
[3]  
Yannas IV, Burke JF., Design of an artificial skin, J Biomed Mater Res, 14, (1980)
[4]  
Brown AS, Barot LR., Biological dressing and skin substitutes, Clin Plast Surg, 13, (1986)
[5]  
Quenn D, Evans JH, Gaylor JDS, Et al., Burn wound dressings: A review, Burns, 13, (1987)
[6]  
Hybrid artificial organs, 177, pp. 13-28, (1989)
[7]  
Jansen JA, van der Waerden JPCM, de Groot K., Fibroblast and epithelial cell interactions with surface–treated implant materials, Biomaterials, 12, (1991)
[8]  
Hansbrough JF, Boyce ST, Cooper ML, Foreman T., Burn wound closure with cultured autologous keratinocytes and fibroblasts attached to a collagen–glycosaminoglycan substrate, JAMA, 262, 15, (1989)
[9]  
Rosdy M, Grisoni B, Clauss LC., Proliferation of normal human keratinocytes on silicone substrates, Biomaterials, 12, pp. 511-517, (1991)
[10]  
Wise DL, Fellmann TD, Sanderson JE, Wentworth RL., Lactic/glycolic acid polymers, Drug carriers in biology and medicine, (1979)