HEREDITARY PARKINSONISM WITH MULTIPLE SYSTEM DEGENERATION - BENEFICIAL EFFECT OF ANTICHOLINERGICS, BUT NOT OF LEVODOPA

被引：9

作者：

MITSUI, T ^{[1
]}

KAWAI, H ^{[1
]}

SAKODA, S ^{[1
]}

MIYATA, M ^{[1
]}

SAITO, S ^{[1
]}

机构：

[1] OSAKA UNIV,SCH MED,DEPT NEUROL,OSAKA 565,JAPAN

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1994年 / 125卷 / 02期

关键词：

HEREDITARY PARKINSONISM; JUVENILE PARKINSONISM; JOSEPHS DISEASE; ANTICHOLINERGICS; LEVODOPA;

D O I：

10.1016/0022-510X(94)90028-0

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Two siblings who exhibited hereditary parkinsonism with pyramidal signs and cerebellar ataxia are reported, Anticholinergics had a dramatic beneficial effect in both cases, but levodopa did not. This responsiveness, which is similar to that reported in patients with Joseph's disease, suggests dysfunction of an ''indirect pathway'' involving the globus pallidus and the subthalamic nucleus, in addition to that of the nigrostriatal system. We propose a new hereditary variant of early onset Parkinson's disease, distinct from the levodopa sensitive forms of juvenile Parkinson's disease.

引用

页码：153 / 157

页数：5

共 31 条

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