PERMISSIVE ROLE OF CORTICOTROPIN-RELEASING FACTOR IN THE ACUTE STRESS-INDUCED PROLACTIN-RELEASE IN FEMALE RATS

被引：18

作者：

AKEMA, T ^{[1
]}

CHIBA, A ^{[1
]}

OSHIDA, M ^{[1
]}

KIMURA, F ^{[1
]}

TOYODA, J ^{[1
]}

机构：

[1] YOKOHAMA CITY UNIV, SCH MED, DEPT PHYSIOL, YOKOHAMA, KANAGAWA 236, JAPAN

来源：

NEUROSCIENCE LETTERS | 1995年 / 198卷 / 02期

关键词：

PROLACTIN; CORTICOTROPIN-RELEASING FACTOR; ALPHA-HELICAL CRF(9-41); IMMOBILIZATION STRESS;

D O I：

10.1016/0304-3940(95)11968-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study examined the role of corticotropin-releasing factor (CRF) in the acute stress-induced release of prolactin (PRL) in ovariectomized estrogen-primed female rats. Acute immobilization stress induced a marked increase in serum PRL levels in animals treated with saline intraventricularly (icy). However, a prior icy injection of alpha-helical CRF(9-41), a CRF antagonist, completely eliminated the immobilization-induced PRL release in the majority of animals, providing evidence for involvement of CRF in the acute stress-induced PRL release. On the other hand, an icy injection of CRF did not affect basal PRL release at any dose in non-stressed animals, suggesting that the peptide plays a permissive role which enables other undefined stress mediator(s) to stimulate PRL release.

引用

页码：146 / 148

页数：3

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