RESHAPING HUMAN-ANTIBODIES - GRAFTING AN ANTILYSOZYME ACTIVITY

被引:291
作者
VERHOEYEN, M [1 ]
MILSTEIN, C [1 ]
WINTER, G [1 ]
机构
[1] MRC,MOLEC BIOL LAB,HILLS RD,CAMBRIDGE CB2 2QH,ENGLAND
关键词
D O I
10.1126/science.2451287
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:1534 / 1536
页数:3
相关论文
共 23 条
  • [1] 3-DIMENSIONAL STRUCTURE OF AN ANTIGEN-ANTIBODY COMPLEX AT 2.8-A RESOLUTION
    AMIT, AG
    MARIUZZA, RA
    PHILLIPS, SEV
    POLJAK, RJ
    [J]. SCIENCE, 1986, 233 (4765) : 747 - 753
  • [2] PRODUCTION OF FUNCTIONAL CHIMAERIC MOUSE HUMAN-ANTIBODY
    BOULIANNE, GL
    HOZUMI, N
    SHULMAN, MJ
    [J]. NATURE, 1984, 312 (5995) : 643 - 646
  • [3] Carson D A, 1986, Adv Immunol, V38, P275, DOI 10.1016/S0065-2776(08)60009-7
  • [4] IMPROVED OLIGONUCLEOTIDE SITE-DIRECTED MUTAGENESIS USING M13 VECTORS
    CARTER, P
    BEDOUELLE, H
    WINTER, G
    [J]. NUCLEIC ACIDS RESEARCH, 1985, 13 (12) : 4431 - 4443
  • [5] CANONICAL STRUCTURES FOR THE HYPERVARIABLE REGIONS OF IMMUNOGLOBULINS
    CHOTHIA, C
    LESK, AM
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1987, 196 (04) : 901 - 917
  • [6] DOMAIN ASSOCIATION IN IMMUNOGLOBULIN MOLECULES - THE PACKING OF VARIABLE DOMAINS
    CHOTHIA, C
    NOVOTNY, J
    BRUCCOLERI, R
    KARPLUS, M
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1985, 186 (03) : 651 - 663
  • [7] TRANSMISSION OF CONFORMATIONAL CHANGE IN INSULIN
    CHOTHIA, C
    LESK, AM
    DODSON, GG
    HODGKIN, DC
    [J]. NATURE, 1983, 302 (5908) : 500 - 505
  • [8] 3-DIMENSIONAL STRUCTURE OF A COMPLEX OF ANTIBODY WITH INFLUENZA-VIRUS NEURAMINIDASE
    COLMAN, PM
    LAVER, WG
    VARGHESE, JN
    BAKER, AT
    TULLOCH, PA
    AIR, GM
    WEBSTER, RG
    [J]. NATURE, 1987, 326 (6111) : 358 - 363
  • [9] EDMUNDSON AB, 1986, SYNTHETIC PEPTIDES A, P107
  • [10] LINKAGE AND SEQUENCE HOMOLOGY OF 2 HUMAN IMMUNOGLOBULIN-GAMMA HEAVY-CHAIN CONSTANT REGION GENES
    ELLISON, J
    HOOD, L
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (06): : 1984 - 1988