NORADRENERGIC CYCLIC-AMP GENERATING SYSTEM IN RAT LIMBIC FOREBRAIN AND ITS STEREOSPECIFICITY FOR BUTACLAMOL

The blocking effect of butaclamol on the specific noradrenergic cyclic AMP generating system in slices of the limbic forebrain also resides in the (+)-enantiomer demonstrating stereospecificity for central noradrenaline receptor blockade. The availability of a stereochemically specific antagonist of a central noradrenaline adenylate cyclase receptor should provide an important tool to further elucidate this system. Although the stereospecific blockade by butaclamol of limbic dopamine receptors is quantitatively more pronounced, these results do support the view that blockade of noradrenergic receptors in the limbic system may also contribute to the pharmacologic and perhaps therapeutic action of antipsychotic drugs.