CHLORDECONE POTENTIATION OF CCL4 HEPATOTOXICITY IN OVARIECTOMIZED RATS

被引：7

作者：

AGARWAL, AK ^{[1
]}

MEHENDALE, HM ^{[1
]}

机构：

[1] UNIV MISSISSIPPI, MED CTR, DEPT PHARMACOL & TOXICOL, JACKSON, MS 39216 USA

来源：

TOXICOLOGY | 1984年 / 29卷 / 04期

关键词：

D O I：

10.1016/0300-483X(84)90163-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Previous reports established the propensity of chlordecone to potentiate the hepatotoxicity and lethality in male and female rats. The present study was designed to investigate the hepatotoxicity of CCl4 in chlordecone (CD) pretreated, ovariectomized rats. Ten days after bilateral ovariectomy, the rats were maintained on a dietary protocol of 0 or 10 ppm chlordecone and on day 15, they received a single i.p. injection of corn oil (1 ml/kg) or 25 .mu.l CCl4/kg in corn oil. Hepatic function, serum enzyme levels and histopathological changes were assessed 24 h after CCl4 challenge as functional biochemical, and morphological parameters of hepatotoxicity. Hepatobiliary function was markedly impaired and serum enzyme levels were elevated in ovariectomized rats receiving the same treatment but not significantly different from normal females receiving the chlordecone and CCl4 combination. Histological findings indicated a greater degree of centrilobular hepatic necrosis accompanied by extensive fatty infiltration. Chlordecone sensitized the liver in ovariectomized rats and amplified the toxic effects of CCl4.

引用

页码：315 / 323

页数：9

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