A FULLY AUTOMATED CHROMATOGRAPHIC PEAK DETECTION AND TREATMENT SOFTWARE FOR MULTIUSER MULTITASK COMPUTERS

被引:10
作者
CARDOT, PJP
TROLLIARD, P
TEMBELY, S
机构
[1] Laboratoire de Chimie Analytique et d'Electrochimie Organique, Faculté de Pharmacie, F-92296 Chatenay Malabry Cedex, Rue Jean Baptiste Clement
关键词
FAST FOURIER TRANSFORM; MOMENTS THEORY; PEAK DESCRIPTION AND DETECTION; UNIX-LIKE COMPUTER SYSTEM; MULTIUSER MULTITASK; NOISE FREQUENCY ANALYSIS AND FILTRATION;
D O I
10.1016/0731-7085(90)80117-8
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A fully automated method is presented for the detection and integration of chromatographic peak software in which the only parameter to define is the data acquisition frequency; this has to be chosen high enough to minimize some Nyquist frequency problems. Programmed in C language, the software is used on a Unix like system (Xenix) to emphasize its automaticity. The performance of the system in liquid chromatography has been studied in respect of noise frequency and intensity. It is shown that the classical signal-to-noise ratio is obsolete for definition of the detection limit since frequency analysis allows some signal filtration; these limitations are described. An example is given of simulation with Gaussian peaks convoluted with noise characterized by its intensity and frequency distribution. The validity of the software is demonstrated for some HPLC separations.
引用
收藏
页码:755 / 759
页数:5
相关论文
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