ALTERED REGIONAL CLEARANCE OF TC-99M-DTPA IN RADIATION PNEUMONITIS

被引：9

作者：

SUGA, K

ARIYOSHI, I

NISHIGAUCHI, K

YOSHIMIZU, T

NAKANISHI, T

UTSUMI, H

YAMADA, N

机构：

[1] Department of Radiology, Yamaguchi University, School of Medicine

[2] Department of Radiology, Yamaguchi University Hospital, Ube

来源：

NUCLEAR MEDICINE COMMUNICATIONS | 1992年 / 13卷 / 05期

关键词：

D O I：

10.1097/00006231-199205000-00010

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Tc-99(m)-diethylene triaminepenta-acetic acid (Tc-99(m)-DTPA) lung scintigrams were investigated in 11 patients with radiation pneumonitis to assess the alteration of clearance of this small solute. Thirty minutes after the injection of Tc-99(m)-DTPA, all 11 patients showed abnormal accumulation. This uptake was seen in the areas with reduced Tc-99(m)-macroaggregated albumin activity. The curves of the lung/heart ratios obtained after 1 min after injection of Tc-99(m)-DTPA in areas showing abnormal accumulation were of three types. Comparison of the slope for the initial 5 min of the lung/heart curves between the abnormal accumulation sites and the contralateral non-irradiated lung revealed a significant difference. The uptake ratio (the mein counts of the last frame divided by initial peak count) was related to the degree of abnormal accumulation in the radiation pneumonitis. Moreover, study of rabbits with radiation pneumonitis revealed similar behaviour by Tc-99(m)-DTPA as observed clinically. This simple and rapid method may be useful in detecting and monitoring the altered regional kinetics of Tc-99(m)-DTPA in radiation pneumonitis.

引用

页码：357 / 364

页数：8

共 16 条

[1]

Peters A.M., George P., Noninvasive measurement of microvascular permeability to small solutes, Nucl Med Commun, 10, pp. 513-521, (1989)

[2]

Harris T.R., Brigham K.L., The exchange of small molecule as a measure of normal and abnormal lung microvascular function, Ann N Y Acad Sci, 384, pp. 417-434, (1982)

[3]

Trap-Jensen J., Increased capillary permeability to 131-iodide and 51-Cr EDTA in the exercising forearm of long term diabetics, Clin Sci, 39, pp. 39-49, (1970)

[4]

Braude S., Nolop K.B., Hugher J.M., Barnes P.J., Royston D., Comparison of lung vascular and epithelial permeability indices in the adult respiratory distress syndrome, Am Rev Respir Dis, 133, pp. 1002-1005, (1986)

[5]

Peters A.M., McKinnon S., Hows J.M., Ballardie F., Non-invasive measurement of microvascular permeability to<sup>99</sup>Tc<sup>m</sup>-DTPA, Clin Sci, 73, pp. 17-47, (1987)

[6]

Peters A.M., Bell S.D., Temporal behavior of peripheral organ distribution volume in mammillary systems, J Nucl Med, 32, pp. 896-897, (1991)

[7]

Decostre P.L., Salmon Y., Temporal behavior of peripheral organ distribution volume in mammillary systems. 1. A new tool for in vivo tracer kinetic analysis, J Nucl Med, 31, pp. 1702-1709, (1990)

[8]

Decostre P.L., Salmon Y., Temporal behavior of peripheral organ distribution volume in mammillary systems. 2. Application to background correction in separate glomerular filtration rate estimation in man, J Nucl Med, 31, pp. 1710-1716, (1990)

[9]

Rahimian J., Glass E.C., Touya J., Akber S.F., Graham S., Bennett L., Measurement of metabolic extraction of tracers in the lung using a multiple indicator dilution technique, J Nucl Med, 25, pp. 31-37, (1984)

[10]

Peters A.M., Measurement of microvascular permeability to small solutes in man: Limitations of the technique, Cardiovasc Res, 24, pp. 504-509, (1990)

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