INHIBITION OF LIPOXYGENASE BY PHENOLIC-COMPOUNDS

被引：23

作者：

DOHI, T ^{[1
]}

ANAMURA, S ^{[1
]}

SHIRAKAWA, M ^{[1
]}

OKAMOTO, H ^{[1
]}

TSUJIMOTO, A ^{[1
]}

机构：

[1] HIROSHIMA UNIV,SCH DENT,DEPT ENDODONTOL & PERIODONTOL,HIROSHIMA 734,JAPAN

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1991年 / 55卷 / 04期

关键词：

D O I：

10.1254/jjp.55.547

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Eugenol dose-dependently inhibited 5-HETE (5-hydroxy-5,8,10,14-eicosatetraenoic acid) and 15-HETE formation by human polymorphonuclear leucocytes. p-Chlorophenol, guaiacol and phenol also inhibited the lipoxygenases. Formation of HETEs by rat dental pulp was inhibited by eugenol and p-chlorophenol. The concentrations of the phenolics required to inhibit lipoxygenases were in the similar range with those used for inhibiting cyclooxygenase. These results showed that phenolic compounds inhibited lipoxygenases and thus suggest that these compounds may be dual inhibitors of lipoxygenase and cyclooxygenase.

引用

页码：547 / 550

页数：4

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