ANTIMYOSIN-LABELED MONOCRYSTALLINE IRON-OXIDE ALLOWS DETECTION OF MYOCARDIAL INFARCT - MR ANTIBODY IMAGING

被引：132

作者：

WEISSLEDER, R ^{[1
]}

LEE, AS ^{[1
]}

KHAW, BA ^{[1
]}

SHEN, T ^{[1
]}

BRADY, TJ ^{[1
]}

机构：

[1] HARVARD UNIV, MED SCH, BOSTON, MA 02129 USA

来源：

RADIOLOGY | 1992年 / 182卷 / 02期

关键词：

HEART; MR; IRON; MAGNETIC RESONANCE (MR); ANTIBODY IMAGING; MYOCARDIUM; INFARCTION;

D O I：

10.1148/radiology.182.2.1732953

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The synthesis and in vivo antigen targeting of a novel iron oxide compound were studied. A monocrystalline iron oxide nanoparticle (MION) was synthesized that contains a small (mean diameter, 2.9 nm +/- 0.9) single crystal core, passes through capillary membranes, and exhibits superpara-magnetism. The MION was attached to antimyosin Fab (R11D10) and used for immunospecific magnetic resonance (MR) imaging of cardiac infarcts. One hour after intravenous administration of MION-R11D10 in rats (100-mu-mol/kg), a marked decrease in the signal intensity of infarcted myocardium was observed. Immunohistochemical correlation confirmed the specific binding of the immunoconjugate to infarcted, but not to normal, myocardium. No decrease in cardiac signal intensity was observed when unconjugated MION was administered intravenously. The results indicate the feasibility of immunospecific MR imaging in living organisms.

引用

页码：381 / 385

页数：5

共 19 条

[1] THE LOW-TEMPERATURE TRANSITION IN MAGNETITE [J].