ARTIFICIAL PROTEIN VACCINES WITH PREDETERMINED TERTIARY STRUCTURE - APPLICATION TO ANTI-HIV-1 VACCINE DESIGN

被引：9

作者：

EROSHKIN, AM ^{[1
]}

ZHILKIN, PA ^{[1
]}

SHAMIN, VV ^{[1
]}

KOROLEY, S ^{[1
]}

FEDOROV, BB ^{[1
]}

机构：

[1] RUSSIAN ACAD SCI,ENGELGARDT INST MOLEC BIOL,MOSCOW 117968,RUSSIA

来源：

PROTEIN ENGINEERING | 1993年 / 6卷 / 08期

关键词：

ANTI-HIV VACCINE; 4-HELIX BUNDLE; PROTEIN VACCINE DESIGN; T-CELL EPITOPES; B-CELL EPITOPES;

D O I：

10.1093/protein/6.8.997

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A successful approach to the development of a safe and effective synthetic vaccine requires that different B and T cell epitopes of the infectious agent be included in the vaccine construction. In this paper we suggest a new approach to vaccine design in the form of an artificial protein with a predetermined tertiary structure (PTS vaccines). Based on B and T cell epitope properties, we substantiate the possible use for vaccine construction of one well-known protein spatial motif-the four-alpha-helix bundle. Antigenic determinants of cellular immunity (amphipathic alpha-helices) and humoral immunity (flexible hydrophilic loop regions) are used as blocks for vaccine design. General principles of PTS vaccine construction have been applied to anti-HIV-1 vaccine design.

引用

页码：997 / 1001

页数：5

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