A PROTEIN RELATED TO A PROTEASOMAL SUBUNIT BINDS TO THE INTRACELLULAR DOMAIN OF THE P55 TNF RECEPTOR UPSTREAM TO ITS DEATH DOMAIN

被引：60

作者：

BOLDIN, MP ^{[1
]}

METT, IL ^{[1
]}

WALLACH, D ^{[1
]}

机构：

[1] WEIZMANN INST SCI,DEPT MEMBRANE RES & BIOPHYS,IL-76100 REHOVOT,ISRAEL

来源：

FEBS LETTERS | 1995年 / 367卷 / 01期

关键词：

DEATH DOMAIN; RECEPTOR; PROTEASOME; SIGNALING; TUMOR NECROSIS FACTOR; 2-HYBRID SYSTEM;

D O I：

10.1016/0014-5793(95)00534-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel protein that binds specifically to the intracellular domain of the p55 tumor necrosis factor (TNF) receptor was cloned by two-hybrid screening of a HeLa cell cDNA library. Data bank searches revealed high sequence similarity of the protein (55.11) to yeast, nematode and plant proteins, whose functions are yet unknown. Significant similarity was also found between 55.11 and SEN3, the yeast equivalent of the p112 subunit of the 26S proteasome. Deletion analysis showed that the protein binds to the p55 receptor upstream to the region involved in induction of cell death.

引用

页码：39 / 44

页数：6

共 25 条

[1] CDNA CLONING AND INTERFERON-GAMMA DOWN-REGULATION OF PROTEASOMAL SUBUNIT-X AND SUBUNIT-Y
AKIYAMA, KY
YOKOTA, KY
KAGAWA, S
SHIMBARA, N
TAMURA, T
AKIOKA, H
NOTHWANG, HG
NODA, C
TANAKA, K
ICHIHARA, A
[J]. SCIENCE, 1994, 265 (5176) : 1231 - 1234
[2] TUMOR NECROSIS, CACHEXIA, SHOCK, AND INFLAMMATION - A COMMON MEDIATOR
BEUTLER, B
CERAMI, A
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1988, 57 : 505 - 518
[3] INTERFERON-GAMMA STIMULATION MODULATES THE PROTEOLYTIC ACTIVITY AND CLEAVAGE SITE PREFERENCE OF 20S MOUSE PROTEASOMES
BOES, B
HENGEL, H
RUPPERT, T
MULTHAUP, G
KOSZINOWSKI, UH
KLOETZEL, PM
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 179 (03) : 901 - 909
[4] A NOVEL PROTEIN THAT INTERACTS WITH THE DEATH DOMAIN OF FAS/APO1 CONTAINS A SEQUENCE MOTIF RELATED TO THE DEATH DOMAIN
BOLDIN, MP
VARFOLOMEEV, EE
PANCER, Z
METT, IL
CAMONIS, JH
WALLACH, D
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (14) : 7795 - 7798
[5] SELF-ASSOCIATION OF THE DEATH DOMAINS OF THE P55 TUMOR-NECROSIS-FACTOR (TNF) RECEPTOR AND FAS/APO1 PROMPTS SIGNALING FOR TNF AND FAS/APO1 EFFECTS
BOLDIN, MP
METT, IL
VARFOLOMEEV, EE
CHUMAKOV, I
SHEMERAVNI, Y
CAMONIS, JH
WALLACH, D
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (01) : 387 - 391
[6] CYTOPLASMIC TRUNCATION OF THE P55 TUMOR-NECROSIS-FACTOR (TNF) RECEPTOR ABOLISHES SIGNALING, BUT NOT INDUCED SHEDDING OF THE RECEPTOR
BRAKEBUSCH, C
NOPHAR, Y
KEMPER, O
ENGELMANN, H
WALLACH, D
[J]. EMBO JOURNAL, 1992, 11 (03) : 943 - 950
[7] BRAKEBUSCH C, 1993, TUMOR NECROSIS FACTO, V4, P40
[8] DEMARTINO GN, 1994, J BIOL CHEM, V269, P20878
[9] A NOVEL GENETIC SYSTEM TO DETECT PROTEIN PROTEIN INTERACTIONS
FIELDS, S
SONG, OK
[J]. NATURE, 1989, 340 (6230) : 245 - 246
[10] SOLUBILIZATION AND PURIFICATION OF ENZYMATICALLY ACTIVE GLUTATHIONE-S-TRANSFERASE (PGEX) FUSION PROTEINS
FRANGIONI, JV
NEEL, BG
[J]. ANALYTICAL BIOCHEMISTRY, 1993, 210 (01) : 179 - 187

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