RISK-FACTORS FOR A FIRST FEBRILE SEIZURE - A MATCHED CASE-CONTROL STUDY

被引:148
作者
BERG, AT
SHINNAR, S
SHAPIRO, ED
SALOMON, ME
CRAIN, EF
HAUSER, WA
机构
[1] ALBERT EINSTEIN COLL MED,DEPT NEUROL,BRONX,NY
[2] ALBERT EINSTEIN COLL MED,DEPT PEDIAT,BRONX,NY
[3] MONTEFIORE EPILEPSY MANAGEMENT CTR,BRONX,NY
[4] COLUMBIA UNIV,SCH MED,GERTRUDE H SERGIEVSKY CTR,NEW YORK,NY
[5] YALE UNIV,SCH MED,DEPT PEDIAT,NEW HAVEN,CT 06510
关键词
FEVER; FEBRILE SEIZURES; RISK FACTORS; FAMILY HISTORY; ACUTE ILLNESS EPISODE; GASTROENTERITIS; MATERNAL SMOKING DURING PREGNANCY;
D O I
10.1111/j.1528-1157.1995.tb01006.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We conducted a matched case-control study to identify risk factors for first febrile seizures, with special emphasis on characteristics of the acute illness episode. Cases were identified through hospital emergency departments; controls were identified through outpatient clinics and emergency departments. Sixty-nine children with first febrile seizures and no history of previous unprovoked seizures were matched for age (+/-6 months), site of routine pediatric care, and date of visit (+/-2 weeks) with 1 or 2 febrile controls who had no history of previous febrile or unprovoked seizures, Medical records for the index visit were reviewed, and parents were interviewed by telephone. Illness characteristics examined included height of temperature, type of underlying illness, contact with a physician during the illness but before the index visit, and use of acetaminophen or decongestants. Family history of febrile and of unprovoked seizures, sociodemographic characteristics, daycare use, and selected pre- and perinatal variables were also studied. On multivariable analysis, significant independent risk factors were height of temperature, history of febrile seizures in a first- or in a higher degree relative. Gastroenteritis as the underlying illness had a significant inverse (i.e., protective) association with febrile seizures. Maternal smoking during pregnancy was a marginally significant predictor of febrile seizures.
引用
收藏
页码:334 / 341
页数:8
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