ETHANOL AND RESPONSE TO ELECTRIC-SHOCK IN RATS

被引：35

作者：

BRICK, J ^{[1
]}

SUN, JY ^{[1
]}

DAVIS, L ^{[1
]}

POHORECKY, LA ^{[1
]}

机构：

[1] ROCKEFELLER UNIV, NEW YORK, NY 10021 USA

来源：

LIFE SCIENCES | 1976年 / 18卷 / 11期

关键词：

D O I：

10.1016/0024-3205(76)90207-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Moderate doses of ethanol (2 g/kg) were found to have an analgesic effect in rats. When tested with either foot- or tail-shock, the animals showed progressive analgesia with increasing levels of ethanol in the blood. The vocalization response seemed to be the most sensitive indicator of this parameter. The analgesic effect of ethanol was decreased by half when serotonin levels in the brain were decreased after treatment of animals with p-chloroamphetamine. Inhibition of catecholamine synthesis with .alpha.-methyl tyrosine had no effect on the analgesic effect of ethanol.

引用

页码：1293 / 1298

页数：6

共 23 条

[1] EFFECT OF ETHANOL ON HYDROXYLATION OF TYROSINE AND TRYPTOPHAN IN RAT-BRAIN IN-VIVO [J].