CHROMOSOMAL LOCALIZATION OF THE MOUSE GENES-CODING FOR ALPHA-2, ALPHA-3, ALPHA-4 AND BETA-2 SUBUNITS OF NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTOR

被引：30

作者：

BESSIS, A ^{[1
]}

SIMONCHAZOTTES, D ^{[1
]}

DEVILLERSTHIERY, A ^{[1
]}

GUENET, JL ^{[1
]}

CHANGEUX, JP ^{[1
]}

机构：

[1] INST PASTEUR,DEPT IMMUNOL,UNITE GENET MAMMIFERES,F-75724 PARIS 15,FRANCE

来源：

FEBS LETTERS | 1990年 / 264卷 / 01期

关键词：

Chromosomal localization; Mouse interspecies cross; Nicotinic receptor; Restriction lenght fragment polymorphism;

D O I：

10.1016/0014-5793(90)80761-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The chromosomal localization of four neuronal nicotinic acetylcholine receptor subunit genes was performed by following the mendelian segregation of their corresponding alleles in backcrosses involving the mouse species Mus spretus and the laboratory strains C57BL/6 or BALB/c. A similar analysis previously performed with muscle nicotinic acetylcholine receptor subunits revealed that the genes coding for the α and β subunits are respectively located on chromosome 2 and 11, whereas the γ and δ subunit coding genes are linked and located on mouse chromosome 1. In this study, we show that the genes coding for the neuronal nicotinic acetylcholine receptor α2, α3 and β2 subunits are dispersed on three different mouse chromosomes, viz. 14, 9 and 3 respectively. Moreover, the α4 subunit gene is located on chromosome 2 but is not genetically linked to the α1 subunit gene. © 1990.

引用

页码：48 / 52

页数：5

共 59 条

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