SPECIFIC HIPPOCAMPAL-LESIONS INDICATE THE PRESENCE OF SULFONYLUREA BINDING-SITES ASSOCIATED TO ATP-SENSITIVE K+ CHANNELS BOTH POST-SYNAPTICALLY AND ON MOSSY FIBERS

被引：43

作者：

MOURRE, C

WIDMANN, C

LAZDUNSKI, M

机构：

[1] Institut de Pharmacologie moléculaire et cellulaire, Sophia Antipolis

来源：

BRAIN RESEARCH | 1991年 / 540卷 / 1-2期

关键词：

GLIBENCLAMIDE; ADENOSINE TRIPHOSPHATE-REGULATED K+ CHANNEL; COLCHICINE; KAINIC ACID; MOSSY FIBER; HIPPOCAMPUS; RAT;

D O I：

10.1016/0006-8993(91)90533-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The density of glibenclamide (GB) binding sites decreases considerably in the dentate gyrus (> 80%), the CA1 field (approximately 75%) and the stratum lucidum of CA3 field (approximately 70%) after intradentate colchicine injections in rat hippocampus. The density of GB receptors is unchanged in kainic acid damaged hippocampus. These data show that GB binding sites associated to adenosine triphosphate-sensitive K+ channels are mainly located in granular cells in both pre- and post-synaptic positions. They are present in mossy fibers.

引用

页码：340 / 344

页数：5

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