ORG2766 IMPROVES PERFORMANCE OF RATS WITH UNILATERAL LESIONS IN THE FIMBRIA FORNIX IN A SPATIAL-LEARNING TASK

被引：49

作者：

SPRUIJT, B ^{[1
]}

PITSIKAS, N ^{[1
]}

ALGERI, S ^{[1
]}

GISPEN, WH ^{[1
]}

机构：

[1] MARIO NEGRI INST PHARMACOL RES,I-20157 MILAN,ITALY

来源：

BRAIN RESEARCH | 1990年 / 527卷 / 02期

关键词：

ACTH[!sub]4-9[!/sub] analog; Avoidance behavior; Fimbria fornix; Functional recovery; Spatial learning;

D O I：

10.1016/0006-8993(90)91137-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

ACTH and related peptides are known for their effects on behavior and for their efficacy on peripheral nerve regeneration. More recently, evidence demonstrating neurotrophic effects of Org2766 on recovery after damage of the central nervous system has become available. Aging studies indicated that particularly the hippocampus appears susceptible to peptide treatment. Therefore, in this study the neurotrophic influence of Org2766 on recovery of hippocampal functioning was studied after transection of the fimbria fornix connection. Analogous to results obtained with recovery of sensorimotor function following peripheral nerve damage a chronic treatment with Org2766 facilitates recovery of the impaired function, i.e. spatial learning in a Morris maze. However, the lesion-induced impairment of avoidance behavior was not influenced by the peptide treatment. © 1990.

引用

页码：192 / 197

页数：6

共 32 条

[1] RETENTION OF A PASSIVE AVOIDANCE RESPONSE AS A FUNCTION OF INTENSITY AND DURATION OF ELECTRIC SHOCK [J].