THE EFFECT OF MALONYLDIALDEHYDE ON VISCOSITY OF NORMAL AND SICKLE RED-BLOOD-CELLS

被引：21

作者：

JAIN, SK

ROSS, JD

LEVY, GJ

DUETT, J

机构：

[1] Department of Pediatrics, Louisiana State University School of Medicine, Shreveport

来源：

BIOCHEMICAL MEDICINE AND METABOLIC BIOLOGY | 1990年 / 44卷 / 01期

关键词：

D O I：

10.1016/0885-4505(90)90042-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study has examined the effect of MDA, an end product of lipid peroxidation, on the viscosity of AA and SS RBC suspensions. MDA accumulation in RBC was accomplished in vitro in human RBC by treating them with exogenous standard MDA. MDA accumulation assessed by the thiobarbituric acid reactivity of in vitro MDA-treated RBC was comparable to that of the RBC in vivo in hemolytic anemias. There was a significant increase in the viscosity of both AA and SS RBC suspensions after in vitro treatment with MDA. The increase in viscosity or RBC was significantly positively correlated with the extent of MDA accumulation. © 1990.

引用

页码：37 / 41

页数：5

共 23 条

[1] FLUORESCENT PRODUCTS OF PHOSPHOLIPIDS DURING LIPID PEROXIDATION [J].