SPINAL SEROTONERGIC AND KAPPA OPIOID RECEPTORS MEDIATE FACILITATION OF THE TAIL FLICK REFLEX PRODUCED BY VAGAL AFFERENT STIMULATION

被引：34

作者：

REN, K

RANDICH, A

GEBHART, GF

机构：

[1] UNIV IOWA, DEPT PHARMACOL, BOWEN SCI BLDG, IOWA CITY, IA 52242 USA

[2] UNIV IOWA, DEPT PSYCHOL, IOWA CITY, IA 52242 USA

来源：

PAIN | 1991年 / 45卷 / 03期

关键词：

DESCENDING FACILITATION; VAGAL AFFERENTS; SPINAL NEUROTRANSMITTERS; TAIL FLICK;

D O I：

10.1016/0304-3959(91)90057-5

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Facilitation of the nociceptive tail flick (TF) reflex produced by low intensity (2.0 msec, 20 Hz) electrical stimulation of cervical vagal afferents (VAS) was studied in rats lightly anesthetized with pentobarbital. Serotonin (methysergide, LY 53857 or ICS 205-930), adrenergic (prazosin or yohimbine) or opioid (naloxone, nor-binaltorphimine or naltrindole) receptor antagonists were administered into the subarachnoid space of the lumbar enlargement to characterize the spinal receptors mediating VAS-produced facilitation. Spinal 5-HT1 and kappa-opioid receptors were determined to be involved in facilitation of the TF reflex produced by VAS, suggesting that facilitation of spinal nociceptive transmission by activation of cervical vagal afferents is mediated by subtypes of spinal serotonergic and opioid receptors.

引用

页码：321 / 329

页数：9

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