EFFECTS OF PRETREATMENT WITH SUBLETHAL ISCHEMIA ON THE EXTRACELLULAR GLUTAMATE CONCENTRATIONS DURING SECONDARY ISCHEMIA IN THE GERBIL HIPPOCAMPUS EVALUATED WITH INTRACEREBRAL MICRODIALYSIS

被引：45

作者：

NAKATA, N

KATO, H

LIU, Y

KOGURE, K

机构：

[1] Department of Neurology, Institute of Brain Diseases, Tohoku University School of Medicine, Sendai

来源：

NEUROSCIENCE LETTERS | 1992年 / 138卷 / 01期

关键词：

CEREBRAL ISCHEMIA; REPEATED ISCHEMIA; SELECTIVE VULNERABILITY; TOLERANCE; GLUTAMATE; EXCITOTOXICITY; MICRODIALYSIS; GERBIL;

D O I：

10.1016/0304-3940(92)90478-P

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To elucidate the role of glutamate in the pathogenesis of altered neuronal vulnerability following sublethal ischemia, we measured the extracellular concentrations of glutamate in the gerbil hippocampus using a microdialysis technique. During and immediately after 3-min forebrain ischemia, the extracellular glutamate level showed a striking increase. However, pretreatment with 2-min ischemia 1 h or 4 days before secondary 3-min ischemia did not alter the amount of glutamate released. The result indicates that cumulative damage and tolerance, which take place after pretreatment with sublethal ischemia, are not induced through modification of the amount of glutamate released during secondary ischemia.

引用

页码：86 / 88

页数：3

共 26 条

[1] CHANGES IN EXTRACELLULAR AMINO-ACIDS AND SPONTANEOUS NEURONAL-ACTIVITY DURING ISCHEMIA AND EXTENDED REFLOW IN THE CA1 OF THE RAT HIPPOCAMPUS [J].