INDUCTION OF MICRONUCLEI IN V79 CHINESE-HAMSTER CELLS BY HYDROQUINONE AND ECONAZOLE NITRATE

被引：11

作者：

ELLARD, S

PARRY, EM

机构：

[1] Molecular Biology Research Group, School of Biological Sciences, University College of Swansea, Swansea, SA2 8PP, Singleton Park

来源：

MUTATION RESEARCH | 1993年 / 287卷 / 01期

关键词：

MICRONUCLEI; INDUCTION; CHINESE HAMSTER CELLS; V79; HYDROQUINONE; ECONAZOLE NITRATE;

D O I：

10.1016/0027-5107(93)90147-8

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Two suspect aneugens (hydroquinone and econazole nitrate) were examined for their ability to induce micronuclei in a number of V79 Chinese hamster cell lines which express rat cytochrome P-450 cDNAs. Hydroquinone elevated micronucleated cell frequencies in a dose-dependent manner in cell lines V79, XEM2 (expresses CYP1A1) and SD1 (expresses CYP2B1). Econazole nitrate was an effective inducer of micronuclei over a narrow dose range in cell lines V79, XEM2 and XEMd-MZ (expresses CYP1A2). The different cell lines showed similar responses to the test agents, indicating that hydroquinone is not a substrate for biotransformation by rat CYP1A1 or CYP2B1, nor is econazole nitrate biotransformed by rat CYP1A1 or CYP1A2.

引用

页码：87 / 91

页数：5

共 31 条

[1] COMPARISON OF SINGLE AND MULTIPLE TREATMENT REGIMENS IN THE MOUSE BONE-MARROW MICRONUCLEUS ASSAY FOR HYDROQUINONE (HQ) AND CYCLOPHOSPHAMIDE (CP) [J].

ADLER, ID ;

KLIESCH, U .

MUTATION RESEARCH, 1990, 234 (3-4) :115-123

[2] MOUSE MICRONUCLEUS TESTS WITH KNOWN AND SUSPECT SPINDLE POISONS - RESULTS FROM 2 LABORATORIES [J].

ADLER, ID ;

KLIESCH, U ;

VANHUMMELEN, P ;

KIRSCHVOLDERS, M .

MUTAGENESIS, 1991, 6 (01) :47-53

[3] INVITRO MICRONUCLEUS TEST WITH KINETOCHORE STAINING - EVALUATION OF TEST-PERFORMANCE [J].

ANTOCCIA, A ;

DEGRASSI, F ;

BATTISTONI, A ;

CILIUTTI, P ;

TANZARELLA, C .

MUTAGENESIS, 1991, 6 (04) :319-324

[4] THE ANALYSIS OF 10 POTENTIAL SPINDLE POISONS FOR THEIR ABILITY TO INDUCE CREST-POSITIVE MICRONUCLEI IN HUMAN-DIPLOID FIBROBLASTS [J].

BONATTI, S ;

CAVALIERI, Z ;

VIAGGI, S ;

ABBONDANDOLO, A .

MUTAGENESIS, 1992, 7 (02) :111-114

[5] CLASTOGENIC EFFECTS OF HYDROQUINONE - INDUCTION OF CHROMOSOMAL-ABERRATIONS IN MOUSE GERM-CELLS [J].

CIRANNI, R ;

ADLER, ID .

MUTATION RESEARCH, 1991, 263 (04) :223-229

[6] IMMUNOFLUORESCENT STAINING OF KINETOCHORES IN MICRONUCLEI - A NEW ASSAY FOR THE DETECTION OF ANEUPLOIDY [J].

DEGRASSI, F ;

TANZARELLA, C .

MUTATION RESEARCH, 1988, 203 (05) :339-345

[7] STABLE EXPRESSION OF RAT CYTOCHROME P-450IIB1 CDNA IN CHINESE-HAMSTER CELLS (V79) AND METABOLIC-ACTIVATION OF AFLATOXIN-B1 [J].

DOEHMER, J ;

DOGRA, S ;

FRIEDBERG, T ;

MONIER, S ;

ADESNIK, M ;

GLATT, H ;

OESCH, F .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (16) :5769-5773

[8]

DOGRA S, 1990, MOL PHARMACOL, V37, P608

[9] KINETOCHORE LOCALIZATION IN MICRONUCLEATED CYTOKINESIS-BLOCKED CHINESE-HAMSTER OVARY CELLS - A NEW AND RAPID ASSAY FOR IDENTIFYING ANEUPLOIDY-INDUCING AGENTS [J].

EASTMOND, DA ;

TUCKER, JD .

MUTATION RESEARCH, 1989, 224 (04) :517-525

[10] IDENTIFICATION OF ANEUPLOIDY-INDUCING AGENTS USING CYTOKINESIS-BLOCKED HUMAN-LYMPHOCYTES AND AN ANTIKINETOCHORE ANTIBODY [J].

EASTMOND, DA ;

TUCKER, JD .

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 1989, 13 (01) :34-43

← 1 2 3 4 →