PRODUCTION OF AN EICOSAPENTAENOIC ACID-CONTAINING OIL BY A DELTA-12 DESATURASE-DEFECTIVE MUTANT OF MORTIERELLA-ALPINA 1S-4

被引:45
作者
JAREONKITMONGKOL, S [1 ]
SHIMIZU, S [1 ]
YAMADA, H [1 ]
机构
[1] KYOTO UNIV,DEPT AGR CHEM,SAKYO KU,KYOTO 606,JAPAN
关键词
DELTA-12; DESATURATION; EICOSAPENTAENOIC ACID; MORTIERELLA-ALPINA; N-3 FATTY ACIDS;
D O I
10.1007/BF02542612
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
A DELTA12 desaturase-defective mutant of an arachidonic acid (AA)-producing fungus, Mortierella alpina 1S-4, converted alpha-linolenic acid (18:3omega3) to 5(Z),8(Z),11(Z),14(Z),17(Z)-eicosapentaenoic acid (EPA). On submerged cultivation at 20-degrees-C for 10 d in a 5-L fermentor containing medium comprising 1% glucose, 1% yeast extract and 3% (vol/vol) linseed oil, EPA production amounted to ca. 1 g/L culture broth (64 mg/g dry mycelium), which accounted for ca. 20% of the total mycelial fatty acids. AA content was 26 mg/g dry mycelium (0.4 g/L), accounting for 7.8% of the total mycelial fatty acids. The other major mycelial fatty acids were palmitic acid (4.5%), oleic acid (20.4%), linoleic acid (10.0%), 18:3omega3 (20.3%) and lignoceric acid (4.3%). Most of the EPA produced (ca. 90 mol%) was in triglyceride form.
引用
收藏
页码:119 / 123
页数:5
相关论文
共 24 条
[1]   DIETARY POLYUNSATURATED FAT IN RELATION TO MAMMARY CARCINOGENESIS IN RATS [J].
BRADEN, LM ;
CARROLL, KK .
LIPIDS, 1986, 21 (04) :285-288
[2]  
CHRISTIE WW, 1982, LIPID ANAL, P53
[3]  
COOK HW, 1991, J LIPID RES, V32, P1265
[4]  
DYERBERG J, 1986, NUTR REV, V44, P125, DOI 10.1111/j.1753-4887.1986.tb07603.x
[5]   INCORPORATION AND METABOLISM OF STEARIC, OLEIC, LINOLEIC AND ALPHA-LINOLENIC ACIDS IN MINIMAL DEVIATION HEPATOMA 7288 C-CELLS [J].
GASPAR, G ;
ALANIZ, MJTD ;
BRENNER, RR .
MOLECULAR AND CELLULAR BIOCHEMISTRY, 1977, 16 (2-3) :197-203
[6]   MOSS CELL-CULTURES AS SOURCES OF ARACHIDONIC AND EICOSAPENTAENOIC ACIDS [J].
HARTMANN, E ;
BEUTELMANN, P ;
VANDEKERKHOVE, O ;
EULER, R ;
KOHN, G .
FEBS LETTERS, 1986, 198 (01) :51-55
[7]  
HULANICKA D, 1964, J BIOL CHEM, V239, P2778
[8]  
IWAMOTO H, 1986, J AM OIL CHEM SOC, V63, P434
[9]   FATTY-ACID DESATURATION-DEFECTIVE MUTANTS OF AN ARACHIDONIC-ACID-PRODUCING FUNGUS, MORTIERELLA-ALPINA 1S-4 [J].
JAREONKITMONGKOL, S ;
SHIMIZU, S ;
YAMADA, H .
JOURNAL OF GENERAL MICROBIOLOGY, 1992, 138 :997-1002
[10]   PRODUCTION OF 5,8,11-CIS-EICOSATRIENOIC ACID BY A DELTA-12-DESATURASE-DEFECTIVE MUTANT OF MORTIERELLA-ALPINA 1S-4 [J].
JAREONKITMONGKOL, S ;
KAWASHIMA, H ;
SHIMIZU, S ;
YAMADA, H .
JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 1992, 69 (09) :939-944