DYNAMIC STRENGTH IN PARKINSONS-DISEASE - QUANTITATIVE MEASUREMENTS FOLLOWING WITHDRAWAL OF MEDICATION

被引：40

作者：

PEDERSEN, SW ^{[1
]}

OBERG, B ^{[1
]}

机构：

[1] LINKOPING UNIV HOSP,DEPT NEUROL,S-58185 LINKOPING,SWEDEN

来源：

EUROPEAN NEUROLOGY | 1993年 / 33卷 / 02期

关键词：

ISOKINETIC STRENGTH; MUSCLE; PARKINSONS DISEASE; PHARMACOLOGY; THERAPY; QUANTITATIVE MEASUREMENT;

D O I：

10.1159/000116913

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This study examined the influence of pharmacological treatment on muscle strength in Parkinson's disease (PD). Twelve patients, 7 men and 5 women, were tested with modified Cybex II equipment. Peak torques in isometric, concentric and eccentric contraction at 30, 120 and 180-degrees/s in ankle dorsiflexors were recorded before and after the withdrawal of medication. EMG were recorded during contraction. Clinical assessment was done according to Webster's and Hoehn and Yahr's rating scales. Clinical scores were significantly increased (p < 0.05). Peak torques in isometric, concentric and eccentric contraction (p < 0.05) decreased at almost all velocities after withdrawal of medication. Correlations were found between changes in clinical score and strength. Strength production in PD was influenced by medication, and the results correlated with changes in clinical ratings. Strength measurement may be used in the evaluation of pharmacological therapy.

引用

页码：97 / 102

页数：6

共 25 条

[1]

AHLQVIST G, 1975, LAB INVEST, V32, P673

[2] SCALING OF THE SIZE OF THE 1ST AGONIST EMG BURST DURING RAPID WRIST MOVEMENTS IN PATIENTS WITH PARKINSONS-DISEASE [J].

BERARDELLI, A ;

DICK, JPR ;

ROTHWELL, JC ;

DAY, BL ;

MARSDEN, CD .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1986, 49 (11) :1273-1279

[3]

BROBERG C, 1983, SCAND J REHABIL MED, V9, P108

[4] ELECTRO-PHYSIOLOGICAL STUDIES OF GAIT IN SPASTICITY AND RIGIDITY - EVIDENCE THAT ALTERED MECHANICAL-PROPERTIES OF MUSCLE CONTRIBUTE TO HYPERTONIA [J].

DIETZ, V ;

QUINTERN, J ;

BERGER, W .

BRAIN, 1981, 104 (SEP) :431-449

[5]

EDSTROM L, 1970, Journal of the Neurological Sciences, V11, P537, DOI 10.1016/0022-510X(70)90104-8

[6]

FASSHAUER K, 1987, NERVENARZT, V58, P49

[7] PARKINSONISM - ONSET PROGRESSION AND MORTALITY [J].

HOEHN, MM ;

YAHR, MD .

NEUROLOGY, 1967, 17 (05) :427-&

[8]

JANCOVIC J, 1987, HDB PARKINSONS DISEA, P90

[9] DISABILITY PROFILES AND OBJECTIVE QUANTITATIVE ASSESSMENT IN PARKINSONS-DISEASE [J].

JOHNELS, B ;

INGVARSSON, PE ;

THORSELIUS, M ;

VALLS, M ;

STEG, G .

ACTA NEUROLOGICA SCANDINAVICA, 1989, 79 (03) :227-238

[10]

KENDALL HO, 1971, MUSCLES TESTING FUNC, P1

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