NICOTINES OPIOID AND ANTI-OPIOID INTERACTIONS - PROPOSED ROLE IN SMOKING-BEHAVIOR

被引：34

作者：

ACETO, MD

SCATES, SM

JI, Z

BOWMAN, ER

机构：

[1] Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY SECTION | 1993年 / 248卷 / 04期

关键词：

NICOTINE; ANTINOCICEPTION; OPIOID AND ANTI-OPIOID INTERACTIONS; SMOKING BEHAVIOR; (MICE);

D O I：

10.1016/0926-6917(93)90009-F

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nicotine produced antinociception in mice which was antagonized noncompetetively by naloxone. In addition, at significantly lower doses, nicotine noncompetitively antagonized morphine-induced antinociception. A speculative suggestion regarding the opiatergic and anti-opiatergic actions of nicotine is that it significantly promotes and maintains smoking behavior.

引用

页码：333 / 335

页数：3

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